Vadim Gladyshev and the Science of Aging

Vadim Gladyshev, PhD, Professor of Medicine at Brigham and Women's Hospital, Harvard Medical School, elected to the National Academy of Science, is a prolific science of aging researcher. We covered many topics including:

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—The nature of aging, and how it is different from biological aging (with glossary below)

—The clocks of biological aging, which he considers biomarkers

proteomic organ clock paper

transcriptomic clock paper

mAge (multimodal) clock with wearable preprint

facial clock (and others to come such as voice, videos)

metabolomic clock paper (from a different group)

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—Transplant of heart from old to young and young to old (preprint) and Rejuvenation

Nature News and Views on that study by Chris Simms

And how this could markedly expand transplant donor organs

Parabiosis studies in mice

—Effect of drugs on biological aging

—slowing of biological aging with anti-fibrotic drug by proteomic clocks

—studies of semaglutide in 5 randomized trials vs placebo, organ proteomic clocks

—AI and aging biology

—Future of aging

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