HDOCK-Multimer：混合建模提升大型蛋白复合物结构预测

Hybrid modeling for improved structure prediction of large protein complexes

Nature Computational Science2026-10-15 08:00未入选

摘要

Nature Computational Science 在线发表的研究提出自动化框架 HDOCK-Multimer（HDM），将从头对接与组合组装结合，用于大型蛋白复合物的结构预测。

摘要由模型根据原文撰写，以原文为准。

正文 · 原文

Nature Computational Science, Published online: 15 October 2026; doi:10.1038/s43588-026-01067-w

An automated framework, HDOCK-Multimer (HDM), is developed that integrates ab initio docking and combinatorial assembly for the structure prediction of large protein complexes. Across three benchmarks, HDM demonstrates increased accuracy and robustness in modeling large protein assemblies, compared with state-of-the-art assembly and deep learning-based methods.

注意转载授权 · 阅读原文

来源：Nature Computational Science · nature.com

引用原文

Nature Computational Science. Hybrid modeling for improved structure prediction of large protein complexes[EB/OL]. (2026-10-15)[访问日期]. https://www.nature.com/articles/s43588-026-01067-w.